| Flora Tallinn |  | - | Lincoln Red Imps FC |  | : | 2-1 |
| The New Saints FC |  | - | SP Tre Penne |  | : | 2-1 |
| FC La Valette |  | - | B36 Torshavn |  | : | 1-0 |
| FC Santa Coloma |  | - | Alashkert FC |  | : | 0-0 |
| Lincoln Red Imps FC | | - | Flora Tallinn | | : | 2-0 (aller 1-2) |
| SP Tre Penne | | - | The New Saints FC | | : | 0-3 (aller 1-2) |
| B36 Torshavn | | - | FC La Valette | | : | 2-1 (aller 0-1) |
| Alashkert FC | | - | FC Santa Coloma | | : | 3-0 (aller 0-0) |
| FK Qarabag Agdam |  | - | F91 Dudelange |  | : | 2-0 |
| Hapoel Beer Sheva FC |  | - | FC Shériff Tiraspol |  | : | 3-2 |
| Olimpija Ljubljana |  | - | FK AS Trencin |  | : | 3-4 |
| Red Bull Salzbourg |  | - | FK Liepaja |  | : | 1-0 |
| FK Vardar Skopje |  | - | GNK Dinamo Zagreb |  | : | 1-2 |
| The New Saints FC | | - | APOEL Nicosie |  | : | 0-0 |
| HSK Zrinjski Mostar |  | - | Legia Varsovie |  | : | 1-1 |
| PFC Ludogorets Razgrad |  | - | FK Mladost Podgorica |  | : | 2-0 |
| FC Dinamo Tbilissi |  | - | Alashkert FC | | : | 2-0 |
| VMFD Zalgiris Vilnius |  | - | FK Astana |  | : | 0-0 |
| FK Partizan Tirana |  | - | Ferencvaros Budapest |  | : | 1-1 |
| BATE Borisov |  | - | SJK Seinäjoki |  | : | 2-0 |
| FC La Valette | | - | Etoile Rouge Belgrade |  | : | 1-2 |
| Rosenborg Trondheim |  | - | IFK Norrköping |  | : | 3-1 |
| Dundalk FC |  | - | FH Hafnarfjördur |  | : | 1-1 |
| Lincoln Red Imps FC | | - | Celtic Glasgow |  | : | 1-0 |
| Crusaders Belfast FC |  | - | FC Copenhague |  | : | 0-3 |
| F91 Dudelange | | - | FK Qarabag Agdam | | : | 1-1 (aller 0-2) |
| FC Shériff Tiraspol | | - | Hapoël Beer Sheva FC | | : | 0-0 (aller 2-3) |
| FK AS Trencin | | - | Olimpija Ljubljana | | : | 2-3 (aller 4-3) |
| FK Liepaja | | - | Red Bull Salzbourg | | : | 0-2 (aller 0-1) |
| GNK Dinamo Zagreb | | - | FK Vardar Skopje | | : | 3-2 (aller 2-1) |
| APOEL Nicosie | | - | The New Saints FC | | : | 3-0 (aller 0-0) |
| Legia Varsovie | | - | HSK Zrinjski Mostar | | : | 2-0 (aller 1-1) |
| FK Mladost Podgorica | | - | PFC Ludogorets Razgrad | | : | 0-3 (aller 0-2) |
| Alashkert FC | | - | FC Dinamo Tbilissi | | : | 1-1 (aller 0-2) |
| FK Astana | | - | VMFD Zalgiris Vilnius | | : | 2-1 (aller 0-0) |
| Ferencvaros Budapest | | - | FK Partizan Tirana | | : | 1-1, 1-3 t.a.b. (aller 1-1) |
| SJK Seinäjoki | | - | BATE Borisov | | : | 2-2 (aller 0-2) |
| Etoile Rouge Belgrade | | - | FC La Valette | | : | 2-1 (aller 2-1) |
| IFK Norrköping | | - | Rosenborg Trondheim | | : | 3-2 (aller 1-3) |
| FH Hafnarfjördur | | - | Dundalk FC | | : | 2-2 (aller 1-1) |
| Celtic Glasgow | | - | Lincoln Red Imps FC | | : | 3-0 (aller 0-1) |
| FC Copenhague | | - | Crusaders Belfast FC | | : | 6-0 (aller 3-0) |
| Rosenborg Trondheim | | - | APOEL Nicosie | | : | 2-1 |
| GNK Dinamo Zagreb | | - | FC Dinamo Tbilissi | | : | 2-0 |
| Olympiakos Le Pirée |  | - | Hapoël Beer Sheva FC | | : | 0-0 |
| FK Astana | | - | Celtic Glasgow | | : | 1-1 |
| FK AS Trencin | | - | Legia Varsovie | | : | 0-1 |
| FC Viktoria Plzen |  | - | FK Qarabag Agdam | | : | 0-0 |
| FC Astra Giurgiu |  | - | FC Copenhague | | : | 1-1 |
| BATE Borisov | | - | Dundalk FC | | : | 1-0 |
| PFC Ludogorets Razgrad | | - | Etoile Rouge Belgrade | | : | 2-2 |
| FK Partizan Tirana | | - | Red Bull Salzbourg | | : | 0-1 |
| Ajax Amsterdam |  | - | PAOK Salonique | | : | 1-1 |
| AC Sparta Prague | | - | Steaua Bucarest | | : | 1-1 |
| Shakhtar Donetsk |  | - | BSC Young Boys Berne |  | : | 2-0 |
| FC Rostov |  | - | RSC Anderlecht |  | : | 2-2 |
| Fenerbahçe Istanbul |  | - | AS Monaco FC |  | : | 2-1 |
| APOEL Nicosie | | - | Rosenborg Trondheim | | : | 3-0 (aller 1-2) |
| FC Dinamo Tbilissi | | - | GNK Dinamo Zagreb | | : | 0-1 (aller 0-2) |
| Hapoël Beer Sheva FC | | - | Olympiakos Le Pirée | | : | 1-0 (aller 0-0) |
| Celtic Glasgow | | - | FK Astana | | : | 2-1 (aller 1-1) |
| Legia Varsovie | | - | FK AS Trencin | | : | 0-0 (aller 1-0) |
| FK Qarabag Agdam | | - | FC Viktoria Plzen | | : | 1-1 (aller 0-0) |
| FC Copenhague | | - | FC Astra Giurgiu | | : | 3-0 (aller 1-1) |
| Dundalk FC | | - | BATE Borisov | | : | 3-0 (aller 0-1) |
| Etoile Rouge Belgrade | | - | PFC Ludogorets Razgrad | | : | 2-4 a.p. (aller 2-2) |
| Red Bull Salzbourg | | - | FK Partizan Tirana | | : | 2-0 (aller 1-0) |
| PAOK Salonique | | - | Ajax Amsterdam | | : | 1-2 (aller 1-1) |
| Steaua Bucarest | | - | AC Sparta Prague | | : | 2-0 (aller 1-1) |
| BSC Young Boys Berne | | - | Shakhtar Donetsk | | : | 2-0, 4-2 t.a.b. (aller 0-2) |
| RSC Anderlecht | | - | FC Rostov | | : | 0-2 (aller 2-2) |
| AS Monaco FC | | - | Fenerbahçe Istanbul | | : | 3-1 (aller 1-2) |
| PFC Ludogorets Razgrad | | - | FC Viktoria Plzen | | : | 2-0 |
| Celtic Glasgow | | - | Hapoël Beer Sheva FC | | : | 5-2 |
| FC Copenhague | | - | APOEL Nicosie | | : | 1-0 |
| Dundalk FC | | - | Legia Varsovie | | : | 0-2 |
| GNK Dinamo Zagreb | | - | Red Bull Salzbourg | | : | 1-1 |
| Steaua Bucarest | | - | Manchester City |  | : | 0-5 |
| FC Porto |  | - | AS Rome |  | : | 1-1 |
| Ajax Amsterdam | | - | FC Rostov | | : | 1-1 |
| BSC Young Boys Berne | | - | Borussia Mönchengladbach |  | : | 1-3 |
| Villarreal CF |  | - | AS Monaco FC | | : | 1-2 |
| FC Viktoria Plzen | | - | PFC Ludogorets Razgrad | | : | 2-2 (aller 0-2) |
| Hapoël Beer Sheva FC | | - | Celtic Glasgow | | : | 2-0 (aller 2-5) |
| APOEL Nicosie | | - | FC Copenhague | | : | 1-1 (aller 0-1) |
| Legia Varsovie | | - | Dundalk FC | | : | 1-1 (aller 2-0) |
| Red Bull Salzbourg | | - | GNK Dinamo Zagreb | | : | 1-2 a.p. (aller 1-1) |
| Manchester City | | - | Steaua Bucarest | | : | 1-0 (aller 5-0) |
| AS Rome | | - | FC Porto | | : | 0-3 (aller 1-1) |
| FC Rostov | | - | Ajax Amsterdam | | : | 4-1 (aller 1-1) |
| Borussia Mönchengladbach | | - | BSC Young Boys Berne | | : | 6-1 (aller 3-1) |
| AS Monaco FC | | - | Villarreal CF | | : | 1-0 (aller 2-1) |